Product Description: DNA helicase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.6.4.12 (DNA helicase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0043596 | nuclear replication fork |
| Component | GO:0005634 | nucleus |
| Function | GO:0036310 | ATP-dependent DNA/DNA annealing activity |
| Function | GO:0008094 | ATP-dependent activity, acting on DNA |
| Function | GO:0003678 | DNA helicase activity |
| Process | GO:0006281 | DNA repair |
| Process | GO:0036292 | DNA rewinding |
| Process | GO:0006974 | cellular response to DNA damage stimulus |
| Process | GO:0031297 | replication fork processing |
| Process | GO:0048478 | replication fork protection |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.11 | 0.94 |
| Trophozoite | expressed | 0.59 | 0.66 |
| Schizont | expressed | 0.59 | 0.65 |
| Gametocyte | expressed | 0.56 | 0.69 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1357500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.306 | #Insertions: 4
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1133800)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1133800)
Modification: Disrupted | RMgm-3105
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IDD0
"Best" AlphaFill ligand hit: AGS (phosphothiophosphoric acid-adenylate ester, Local RMSD=0.77) with 3MWY (Global RMSD=9.41)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.6.4.12 | DNA helicase | No BRENDA inhibitors |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101361
Most Similar Human Ortholog: F8WCT9
TM-align score: 0.79 | RMSD: 3.38
Seq Identity: 0.31 | Length: 390 / 906
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000121988 | zinc finger RANBP2-type containing 3 |
| ENSG00000138375 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 37 | 36 | 55 |
| disruptive | 13 | 57 | 37 | 101 |
| missense | 13 | 56 | 35 | 87 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 19 | 99 | 30 | 44 |
| disruptive | 28 | 154 | 60 | 155 |
| missense | 23 | 128 | 49 | 111 |
PlasmoDB Total SNPs: 79
Non-coding: 36 | Synonymous: 32 | Nonsynonymous: 11 | Stop Codon: 0
Protein Length: 906 | Molecular Weight (kDa): 106.29
UniProt ID(s): Q8IDD0
PDB ID(s): None
Isoelectric Point: 9.06
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000330 | SNF2-related, N-terminal domain |
| InterPro | IPR001650 | Helicase, C-terminal |
| InterPro | IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR030101 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 |
| PFam | PF00176 | SNF2-related, N-terminal domain |
| PFam | PF00271 | Helicase, C-terminal |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
No associated publications