Genome location: Pf3D7_13_v3:2,285,945..2,291,193(-)
Genome classification: Core
Product Description: U3 small nucleolar RNA-associated protein 21, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005730 | nucleolus |
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.72 | 0.67 |
| Trophozoite | expressed | 0.51 | 0.72 |
| Schizont | possibly expressed | 0.10 | 0.94 |
| Gametocyte | possibly expressed | 0.50 | 0.72 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1357700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.13 | MFS: -2.866 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1134000)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A5K1K903
"Best" AlphaFill ligand hit: BU3 ((r,r)-2,3-butanediol, Local RMSD=0.48) with 6YHN (Global RMSD=21.07)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102184
Most Similar Human Ortholog: A0A0A0MTB8
TM-align score: 0.87 | RMSD: 3.23
Seq Identity: 0.21 | Length: 837 / 1218
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000134987 | WD repeat domain 36 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 81 | 47 | 98 |
| disruptive | 32 | 182 | 85 | 270 |
| missense | 32 | 176 | 84 | 259 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 25 | 148 | 53 | 105 |
| disruptive | 66 | 366 | 163 | 299 |
| missense | 58 | 342 | 155 | 246 |
PlasmoDB Total SNPs: 207
Non-coding: 120 | Synonymous: 51 | Nonsynonymous: 36 | Stop Codon: 0
Protein Length: 1218 | Molecular Weight (kDa): 143.36
UniProt ID(s): A0A5K1K903
PDB ID(s): None
Isoelectric Point: 6.33
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007319 | Small-subunit processome, Utp21 |
| InterPro | IPR011047 | Quinoprotein alcohol dehydrogenase-like superfamily |
| PFam | PF04192 | Small-subunit processome, Utp21 |
| Superfamily | SSF50998 | Quinoprotein alcohol dehydrogenase-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 15871019 | Novel interaction of the Hsp90 chaperone machine with Ssl2, an essential DNAhelicase in Saccharomyces cerevisiae | Flom G, Weekes J, Johnson JL | 10.1007/s00294-005-0580-6 |
| 33789348 | Disrupting progression of the yeast Hsp90 folding pathway at different transitionpoints results in client-specific maturation defects | Hohrman K, Goncalves D, Morano KA, Johnson JL | 10.1093/genetics/iyab009 |
| 19150991 | Glaucoma-associated WDR36 variants encode functional defects in a yeast modelsystem | Footz TK, Johnson JL, ..., Walter MA | 10.1093/hmg/ddp027 |
| 32524281 | Anti-infective nitazoxanide disrupts transcription of ribosome biogenesis-relatedgenes in yeast | Xu S, Yamamoto N | 10.1007/s13258-020-00958-0 |