Genome location: Pf3D7_13_v3:2,291,061..2,295,045(+)
Genome classification: Core
Product Description: T-complex protein 1 subunit delta
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005832 | chaperonin-containing T-complex |
| Component | GO:0005829 | cytosol |
| Component | GO:0005634 | nucleus |
| Function | GO:0051082 | unfolded protein binding |
| Process | GO:0006457 | protein folding |
| Process | GO:0009410 | response to xenobiotic stimulus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.66 | 0.69 |
| Trophozoite | expressed | 0.94 | 0.52 |
| Schizont | expressed | 0.11 | 0.94 |
| Gametocyte | expressed | 0.41 | 0.77 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1357800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.119 | MFS: -3.006 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1134100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H5I7
"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.71) with 1Q3S (Global RMSD=2.85)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101757
Most Similar Human Ortholog: P50991
TM-align score: 0.96 | RMSD: 1.25
Seq Identity: 0.59 | Length: 516 / 529
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000115484 | chaperonin containing TCP1 subunit 4 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 52 | 25 | 44 |
| disruptive | 1 | 11 | 10 | 34 |
| missense | 1 | 11 | 9 | 32 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 101 | 23 | 37 |
| disruptive | 5 | 27 | 36 | 76 |
| missense | 2 | 25 | 36 | 58 |
PlasmoDB Total SNPs: 128
Non-coding: 101 | Synonymous: 23 | Nonsynonymous: 2 | Stop Codon: 2
Protein Length: 529 | Molecular Weight (kDa): 57.978
UniProt ID(s): C0H5I7
PDB ID(s): None
Isoelectric Point: 6.82
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002194 | Chaperonin TCP-1, conserved site |
| InterPro | IPR002423 | Chaperonin Cpn60/TCP-1 family |
| InterPro | IPR012717 | T-complex protein 1, delta subunit |
| InterPro | IPR017998 | Chaperone tailless complex polypeptide 1 (TCP-1) |
| InterPro | IPR027409 | GroEL-like apical domain superfamily |
| InterPro | IPR027410 | TCP-1-like chaperonin intermediate domain superfamily |
| InterPro | IPR027413 | GroEL-like equatorial domain superfamily |
| PFam | PF00118 | Chaperonin Cpn60/TCP-1 family |
| Superfamily | SSF48592 | GroEL-like equatorial domain superfamily |
| Superfamily | SSF52029 | GroEL-like apical domain superfamily |
| Superfamily | SSF54849 | TCP-1-like chaperonin intermediate domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 25615740 | New Export Pathway in Plasmodium falciparum-Infected Erythrocytes: Role of theParasite Group II Chaperonin, PfTRiC. | Mbengue A, Vialla E, ..., Braun-Breton C | 10.1111/tra.12266 |
| 28067475 | The chaperonin T RiC forms an oligomeric complex in the malaria parasite cytosol | Spillman NJ, Beck JR, ..., Goldberg DE | 10.1111/cmi.12719 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 32127489 | Plasmodium chaperonin TRiC/CCT identified as a target of the antihistamineclemastine using parallel chemoproteomic strategy. | Lu KY, Quan B, ..., Derbyshire ER | 10.1073/pnas.1913525117 |
| 36607310 | A genome-wide CRISPR screen identifies the CCT chaperonin as a critical regulatorof vesicle trafficking | Chen Y, Kang J, ..., Chen C | 10.1096/fj.202201580R |