PF3D7_1358100

Genome location: Pf3D7_13_v3:2,305,078..2,308,166(-)

Genome classification: Core

Function and Localization

Product Description: Sas10 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	1.58	0.36
Trophozoite	expressed	1.29	0.38
Schizont	expressed	0.44	0.74
Gametocyte	expressed	1.16	0.41

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1358100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.173 | MFS: -2.811 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K911

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104545

Most Similar Human Ortholog: Q9NQZ2

TM-align score: 0.28 | RMSD: 5.77

Seq Identity: 0.16 | Length: 178 / 734

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000132467	UTP3 small subunit processome component

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	15	42	24	40
disruptive	50	176	96	226
missense	20	111	57	149

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	22	75	37	46
disruptive	104	359	150	253
missense	50	228	93	148

PlasmoDB Total SNPs: 191

Non-coding: 55 | Synonymous: 79 | Nonsynonymous: 57 | Stop Codon: 0

Protein Information

Protein Length: 734 | Molecular Weight (kDa): 88.681

UniProt ID(s): A0A5K1K911

PDB ID(s): None

Isoelectric Point: 4.36

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR007146	Sas10/Utp3/C1D
InterPro	IPR018972	Sas10 C-terminal domain
PFam	PF04000	Sas10/Utp3/C1D
PFam	PF09368	Sas10 C-terminal domain
Superfamily	N/A	N/A