PF3D7_1358200

Genome location: Pf3D7_13_v3:2,308,497..2,314,416(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.90	0.60
Trophozoite	expressed	0.85	0.54
Schizont	expressed	0.36	0.78
Gametocyte	possibly expressed	0.51	0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1358200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.13 | MFS: -3.165 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5I8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533125

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	20	104	56	87
disruptive	105	383	188	434
missense	71	314	168	344

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	35	190	75	102
disruptive	198	736	262	530
missense	122	611	208	332

PlasmoDB Total SNPs: 270

Non-coding: 57 | Synonymous: 83 | Nonsynonymous: 128 | Stop Codon: 2

Protein Information

Protein Length: 1596 | Molecular Weight (kDa): 191.46

UniProt ID(s): C0H5I8

PDB ID(s): None

Isoelectric Point: 6.21

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A