PF3D7_1358400

Genome location: Pf3D7_13_v3:2,316,496..2,318,408(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.01	0.99
Trophozoite	possibly expressed	0.05	0.97
Schizont	possibly expressed	0.38	0.75
Gametocyte	possibly expressed	0.27	0.83

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1358400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.992 | MFS: -2.599 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K9A9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533340

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 111

Non-coding: 98 | Synonymous: 8 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 139 | Molecular Weight (kDa): 16.692

UniProt ID(s): A0A5K1K9A9

PDB ID(s): None

Isoelectric Point: 4.57

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A