PF3D7_1358500

Genome location: Pf3D7_13_v3:2,318,416..2,321,089(+)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Component	GO:0005634	nucleus
Function	GO:0008270	zinc ion binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.23	0.89
Trophozoite	expressed	0.41	0.78
Schizont	not expressed	0.05	0.97
Gametocyte	not expressed	0.19	0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1358500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.177 | MFS: -3.235 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDC0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101443

Most Similar Human Ortholog: H7C449

TM-align score: 0.54 | RMSD: 3.05

Seq Identity: 0.30 | Length: 70 / 613

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000109917	ZPR1 zinc finger

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	36	17	35
disruptive	37	83	45	114
missense	17	54	35	89

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	57	25	56
disruptive	50	169	65	162
missense	22	121	50	107

PlasmoDB Total SNPs: 148

Non-coding: 74 | Synonymous: 35 | Nonsynonymous: 38 | Stop Codon: 1

Protein Information

Protein Length: 613 | Molecular Weight (kDa): 70.285

UniProt ID(s): Q8IDC0

PDB ID(s): None

Isoelectric Point: 4.52

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR004457	Zinc finger, ZPR1-type
InterPro	IPR040141	ZPR1 family
PFam	PF03367	Zinc finger, ZPR1-type
Superfamily	N/A	N/A