PF3D7_1358600

Genome location: Pf3D7_13_v3:2,322,060..2,325,077(+)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.98
Trophozoite	possibly expressed	0.04	0.98
Schizont	not expressed	0.47	0.73
Gametocyte	expressed	1.89	0.39

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1358600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 1.384 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1134900)

Modification: Mutated | RMgm-5143

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8I4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_134260

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	52	27	74
disruptive	39	190	77	207
missense	24	162	64	174

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	21	112	49	63
disruptive	83	357	152	287
missense	55	293	127	209

PlasmoDB Total SNPs: 116

Non-coding: 0 | Synonymous: 63 | Nonsynonymous: 52 | Stop Codon: 1

Protein Information

Protein Length: 1005 | Molecular Weight (kDa): 118.299

UniProt ID(s): A0A5K1K8I4

PDB ID(s): None

Isoelectric Point: 6.67

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000571	Zinc finger, CCCH-type
InterPro	IPR036855	Zinc finger, CCCH-type superfamily
PFam	N/A	N/A
Superfamily	SSF90229	Zinc finger, CCCH-type superfamily