PF3D7_1358700 (YOP1L)

Genome location: Pf3D7_13_v3:2,325,473..2,328,323(-)

Genome classification: Core

Function and Localization

Product Description: YOP1-like protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.29	0.85
Trophozoite	expressed	0.31	0.80
Schizont	expressed	0.38	0.75
Gametocyte	expressed	0.16	0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1358700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.148 | MFS: -2.98 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDB8

"Best" AlphaFill ligand hit: 37X (octyl glucose neopentyl glycol, Local RMSD=0.57) with 6Y7F (Global RMSD=14.68)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_136847

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 155

Non-coding: 149 | Synonymous: 6 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 153 | Molecular Weight (kDa): 18.422

UniProt ID(s): Q8IDB8

PDB ID(s): None

Isoelectric Point: 9.7

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR004345	TB2/DP1/HVA22-related protein
PFam	PF03134	TB2/DP1/HVA22-related protein
Superfamily	N/A	N/A