Genome location: Pf3D7_13_v3:2,329,517..2,331,678(+)
Genome classification: Core
Product Description: 40S ribosomal protein S15
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0020036 | Maurer's cleft |
Component | GO:0022627 | cytosolic small ribosomal subunit |
Component | GO:0005730 | nucleolus |
Component | GO:0005634 | nucleus |
Function | GO:0003723 | RNA binding |
Function | GO:0070181 | small ribosomal subunit rRNA binding |
Function | GO:0003735 | structural constituent of ribosome |
Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | no data | N/A | N/A |
Ring | no data | 2.34 | 0.21 |
Trophozoite | no data | 2.77 | 0.08 |
Schizont | no data | 0.74 | 0.61 |
Gametocyte | no data | 1.70 | 0.25 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1358800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.168 | MFS: -3.402 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1135100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IDB0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100971
Most Similar Human Ortholog: P62277
TM-align score: 0.99 | RMSD: 0.47
Seq Identity: 0.66 | Length: 151 / 151
All Human Orthologs (OrthoMCL):
Gene ID | Description |
---|---|
ENSG00000110700 | ribosomal protein S13 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 0 | 10 | 5 | 16 |
disruptive | 0 | 1 | 2 | 8 |
missense | 0 | 1 | 1 | 6 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 2 | 24 | 6 | 13 |
disruptive | 0 | 10 | 12 | 39 |
missense | 0 | 4 | 7 | 19 |
PlasmoDB Total SNPs: 97
Non-coding: 93 | Synonymous: 3 | Nonsynonymous: 0 | Stop Codon: 1
Protein Length: 151 | Molecular Weight (kDa): 17.25
UniProt ID(s): Q8IDB0
PDB ID(s): 3J7A, 3JBN, 3JBO, 3JBP
Isoelectric Point: 11.05
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR000589 | Ribosomal protein S15 |
InterPro | IPR009068 | S15/NS1, RNA-binding |
InterPro | IPR012606 | Ribosomal protein S13/S15, N-terminal |
InterPro | IPR023029 | Ribosomal protein S15P |
PFam | PF00312 | Ribosomal protein S15 |
PFam | PF08069 | Ribosomal protein S13/S15, N-terminal |
Superfamily | SSF47060 | S15/NS1, RNA-binding |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
24913268 | Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine | Wong W, Bai XC, ..., Scheres SH | 10.7554/eLife.03080 |
30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |
33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |