About Gene List

PF3D7_1358800 (RPS15)

Genome location: Pf3D7_13_v3:2,329,517..2,331,678(+)

Genome classification: Core

Function and Localization

Product Description: 40S ribosomal protein S15

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:0022627 cytosolic small ribosomal subunit
Component GO:0005730 nucleolus
Component GO:0005634 nucleus
Function GO:0003723 RNA binding
Function GO:0070181 small ribosomal subunit rRNA binding
Function GO:0003735 structural constituent of ribosome
Process GO:0006412 translation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data 2.34 0.21
Trophozoite no data 2.77 0.08
Schizont no data 0.74 0.61
Gametocyte no data 1.70 0.25

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1358800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.168 | MFS: -3.402 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1135100)

  • Relative Growth Rate: 0.04 ± 0.05
  • Confidence: 7.23

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDB0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100971

Most Similar Human Ortholog: P62277

TM-align score: 0.99 | RMSD: 0.47

Seq Identity: 0.66 | Length: 151 / 151

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000110700 ribosomal protein S13

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 10 5 16
disruptive 0 1 2 8
missense 0 1 1 6

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 2 24 6 13
disruptive 0 10 12 39
missense 0 4 7 19

PlasmoDB Total SNPs: 97

Non-coding: 93 | Synonymous: 3 | Nonsynonymous: 0 | Stop Codon: 1

Protein Information

Protein Length: 151 | Molecular Weight (kDa): 17.25

UniProt ID(s): Q8IDB0

PDB ID(s): 3J7A, 3JBN, 3JBO, 3JBP

Isoelectric Point: 11.05

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000589 Ribosomal protein S15
InterPro IPR009068 S15/NS1, RNA-binding
InterPro IPR012606 Ribosomal protein S13/S15, N-terminal
InterPro IPR023029 Ribosomal protein S15P
PFam PF00312 Ribosomal protein S15
PFam PF08069 Ribosomal protein S13/S15, N-terminal
Superfamily SSF47060 S15/NS1, RNA-binding

Associated Publications

PMID Title Authors DOI/Link
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
24913268 Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine Wong W, Bai XC, ..., Scheres SH 10.7554/eLife.03080
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596
31631203 A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. Das D, Krishnan SR, Roy A, Bulusu G 10.1039/c9mo00124g
33906926 Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH Sinha A, Baumgarten S, ..., Scherf A 10.1128/mBio.00661-21