Product Description: GTP-binding protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 6.1.1.3 (Threonine--tRNA ligase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Function | GO:0005525 | GTP binding |
| Process | GO:0002181 | cytoplasmic translation |
| Process | GO:0007165 | signal transduction |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.13 | 0.94 |
| Trophozoite | expressed | 0.28 | 0.82 |
| Schizont | possibly expressed | 0.03 | 0.98 |
| Gametocyte | expressed | 0.16 | 0.90 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1358900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.195 | MFS: -2.9 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H5I9
"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=0.29) with 5M04 (Global RMSD=4.36)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 6.1.1.3 | threonine-tRNA ligase | borrelidinthreonyl-AMPZINC27215482ZINC67910544ZINC72320615ZINC72320626ZINC35270978ZINC35458951hydrogen peroxideoperator mRNA domain 2tubercidin 5'-triphosphatePurineriboside 5'-triphosphate... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101808
Most Similar Human Ortholog: P55039
TM-align score: 0.94 | RMSD: 1.93
Seq Identity: 0.59 | Length: 363 / 367
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000108591 | developmentally regulated GTP binding protein 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 21 | 15 | 29 |
| disruptive | 2 | 16 | 17 | 35 |
| missense | 2 | 15 | 16 | 31 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 46 | 23 | 26 |
| disruptive | 5 | 39 | 30 | 66 |
| missense | 4 | 34 | 27 | 56 |
PlasmoDB Total SNPs: 213
Non-coding: 192 | Synonymous: 14 | Nonsynonymous: 6 | Stop Codon: 1
Protein Length: 367 | Molecular Weight (kDa): 41.574
UniProt ID(s): C0H5I9
PDB ID(s): None
Isoelectric Point: 9.74
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004095 | TGS |
| InterPro | IPR005225 | Small GTP-binding protein domain |
| InterPro | IPR006073 | GTP binding domain |
| InterPro | IPR006074 | GTP1/OBG, conserved site |
| InterPro | IPR012676 | TGS-like |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR031662 | GTP binding protein, second domain |
| PFam | PF01926 | GTP binding domain |
| PFam | PF02824 | TGS |
| PFam | PF16897 | GTP binding protein, second domain |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| Superfamily | SSF81271 | TGS-like |
No associated publications