PF3D7_1359000

Genome location: Pf3D7_13_v3:2,335,486..2,346,648(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	1.50	0.38
Trophozoite	expressed	0.90	0.53
Schizont	not expressed	0.30	0.83
Gametocyte	not expressed	1.03	0.48

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1359000

Resistome Missense Mutations: E1497K

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 2 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.154 | MFS: -3.196 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102005

Most Similar Human Ortholog: Not available

TM-align score: 0.00 | RMSD: 0.00

Seq Identity: 0.00 | Length: / 3281

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000119285	HEAT repeat containing 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	29	157	100	221
disruptive	112	472	263	598
missense	83	417	230	524

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	56	313	160	248
disruptive	215	967	426	837
missense	150	794	362	616

PlasmoDB Total SNPs: 384

Non-coding: 84 | Synonymous: 139 | Nonsynonymous: 159 | Stop Codon: 2

Protein Information

Protein Length: 3281 | Molecular Weight (kDa): 394.592

UniProt ID(s): C0H5J0

PDB ID(s): None

Isoelectric Point: 9.03

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR010301	Nucleolar, Nop52
PFam	N/A	N/A
Superfamily	N/A	N/A