Genome location: Pf3D7_13_v3:2,358,469..2,362,433(-)
Genome classification: Core
Product Description: CUGBP Elav-like family member 1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Component | GO:1990904 | ribonucleoprotein complex |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003729 | mRNA binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.58 | 0.72 |
| Trophozoite | expressed | 0.62 | 0.65 |
| Schizont | expressed | 0.25 | 0.84 |
| Gametocyte | expressed | 0.35 | 0.79 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1359400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.305 | MFS: -2.595 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0909800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IDB7
"Best" AlphaFill ligand hit: ADE (adenine, Local RMSD=3.22) with 3LQV (Global RMSD=8.80)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100683
Most Similar Human Ortholog: K7EPX2
TM-align score: 0.72 | RMSD: 2.03
Seq Identity: 0.36 | Length: 56 / 509
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000101489 | CUGBP Elav-like family member 4 |
| ENSG00000140488 | CUGBP Elav-like family member 6 |
| ENSG00000159409 | CUGBP Elav-like family member 3 |
| ENSG00000161082 | CUGBP Elav-like family member 5 |
| ENSG00000273025 | novel transcript |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 42 | 25 | 38 |
| disruptive | 5 | 21 | 9 | 33 |
| missense | 5 | 21 | 9 | 31 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 18 | 75 | 24 | 24 |
| disruptive | 10 | 52 | 36 | 111 |
| missense | 8 | 43 | 29 | 84 |
PlasmoDB Total SNPs: 231
Non-coding: 213 | Synonymous: 12 | Nonsynonymous: 4 | Stop Codon: 2
Protein Length: 509 | Molecular Weight (kDa): 57.115
UniProt ID(s): Q8IDB7
PDB ID(s): None
Isoelectric Point: 5.27
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000504 | RNA recognition motif domain |
| InterPro | IPR001202 | WW domain |
| InterPro | IPR002343 | Paraneoplastic encephalomyelitis antigen |
| InterPro | IPR035979 | RNA-binding domain superfamily |
| InterPro | IPR036020 | WW domain superfamily |
| PFam | PF00076 | RNA recognition motif domain |
| PFam | PF00397 | WW domain |
| Superfamily | SSF51045 | WW domain superfamily |
| Superfamily | SSF54928 | RNA-binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 25447287 | Molecular characterization of Plasmodium falciparum Bruno/CELF RNA bindingproteins. | Wongsombat C, Aroonsri A, ..., Shaw PJ | https://pubmed.ncbi.nlm.nih.gov/25447287/ |
| 27381095 | The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. | Bunnik EM, Batugedara G, ..., Le Roch KG | 10.1186/s13059-016-1014-0 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |