PF3D7_1359500

Genome location: Pf3D7_13_v3:2,364,426..2,365,235(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.12	0.94
Trophozoite	no data	0.09	0.95
Schizont	no data	0.03	0.98
Gametocyte	no data	0.26	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1359500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 1.831 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5J1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533180

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	23	11	25
disruptive	7	28	23	57
missense	7	28	23	50

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	41	17	19
disruptive	14	81	45	102
missense	12	70	40	68

PlasmoDB Total SNPs: 19

Non-coding: 1 | Synonymous: 9 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 269 | Molecular Weight (kDa): 31.697

UniProt ID(s): C0H5J1

PDB ID(s): None

Isoelectric Point: 10.23

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A