PF3D7_1359700

Genome location: Pf3D7_13_v3:2,379,985..2,393,171(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.21	0.90
Trophozoite	not expressed	0.51	0.73
Schizont	possibly expressed	1.63	0.33
Gametocyte	not expressed	0.37	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1359700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.602 | #Insertions: 23

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1135900)

Relative Growth Rate: 1.00 ± 0.19
Confidence: 4.73

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1135900)

Modification: Disrupted | RMgm-3113

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_112372

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	33	189	107	273
disruptive	152	640	351	774
missense	105	572	327	697

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	68	354	163	274
disruptive	293	1261	555	1064
missense	206	1107	472	794

PlasmoDB Total SNPs: 522

Non-coding: 115 | Synonymous: 198 | Nonsynonymous: 208 | Stop Codon: 1

Protein Information

Protein Length: 3698 | Molecular Weight (kDa): 439.913

UniProt ID(s): C0H5J3

PDB ID(s): None

Isoelectric Point: 7.76

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A