PF3D7_1359800

Genome location: Pf3D7_13_v3:2,393,370..2,394,355(+)

Genome classification: Core

Function and Localization

Product Description: ADP-ribosylation factor, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Component	GO:0005802	trans-Golgi network
Function	GO:0005525	GTP binding
Function	GO:0003924	GTPase activity
Process	GO:0006886	intracellular protein transport
Process	GO:0006471	protein ADP-ribosylation
Process	GO:1903292	protein localization to Golgi membrane
Process	GO:0016192	vesicle-mediated transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.02	0.99
Trophozoite	no data	0.01	0.99
Schizont	no data	0.22	0.87
Gametocyte	no data	0.21	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1359800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.212 | MFS: -3.176 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDA7

"Best" AlphaFill ligand hit: GTP (guanosine-5'-triphosphate, Local RMSD=0.05) with 2H57 (Global RMSD=2.45)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_134724

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	20	5	15
disruptive	2	14	14	20
missense	2	13	14	20

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	26	11	17
disruptive	8	36	26	48
missense	6	33	24	34

PlasmoDB Total SNPs: 37

Non-coding: 20 | Synonymous: 11 | Nonsynonymous: 5 | Stop Codon: 1

Protein Information

Protein Length: 203 | Molecular Weight (kDa): 23.882

UniProt ID(s): Q8IDA7

PDB ID(s): None

Isoelectric Point: 7.3

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006689	Small GTPase superfamily, ARF/SAR type
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
PFam	PF00025	Small GTPase superfamily, ARF/SAR type
Superfamily	SSF52540	P-loop containing nucleoside triphosphate hydrolase