PF3D7_1359900 (QRP1)

Genome location: Pf3D7_13_v3:2,395,314..2,402,848(+)

Genome classification: Core

Function and Localization

Product Description: quinoxaline resistance protein QRP1

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Process	GO:0009410	response to xenobiotic stimulus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	1.09	0.52
Trophozoite	not expressed	1.11	0.47
Schizont	not expressed	1.49	0.33
Gametocyte	not expressed	1.29	0.39

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1359900

Resistome Missense Mutations: G1612V, D1863Y

Resistome Compounds with Missense Mutations: MMV665794

Resistome # Samples with Disruptive Mutations: 6 (5 missense, 2 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.815 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K916

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_156430

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	18	105	75	166
disruptive	71	274	151	356
missense	49	244	142	305

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	36	224	93	155
disruptive	154	536	248	493
missense	102	458	212	347

PlasmoDB Total SNPs: 317

Non-coding: 114 | Synonymous: 117 | Nonsynonymous: 86 | Stop Codon: 0

Protein Information

Protein Length: 2126 | Molecular Weight (kDa): 249.76

UniProt ID(s): A0A5K1K916

PDB ID(s): None

Isoelectric Point: 9.77

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A