About Gene List

PF3D7_1360000

Genome location: Pf3D7_13_v3:2,403,511..2,404,044(-)

Genome classification: Core

Function and Localization

Product Description: ATP synthase-associated protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring possibly expressed 0.01 0.99
Trophozoite not expressed 0.06 0.96
Schizont not expressed 0.02 0.99
Gametocyte possibly expressed 0.12 0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1360000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.124 | MFS: -3.107 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K943

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_149565

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 8 7 14
disruptive 1 5 8 12
missense 1 5 8 11

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 4 23 8 10
disruptive 2 25 9 22
missense 2 19 6 19

PlasmoDB Total SNPs: 18

Non-coding: 0 | Synonymous: 17 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 177 | Molecular Weight (kDa): 21.562

UniProt ID(s): A0A5K1K943

PDB ID(s): None

Isoelectric Point: 10.03

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16002397 The opportunistic pathogen Toxoplasma gondii deploys a diverse legion of invasionand survival proteins. Zhou XW, Kafsack BF, ..., Carruthers VB 10.1074/jbc.M504160200
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21