Genome location: Pf3D7_13_v3:2,404,623..2,406,467(-)
Genome classification: Core
Product Description: RNA-binding protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Component | GO:0097526 | spliceosomal tri-snRNP complex |
| Function | GO:0003729 | mRNA binding |
| Process | GO:0048024 | regulation of mRNA splicing, via spliceosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.08 | 0.96 |
| Trophozoite | expressed | 0.12 | 0.92 |
| Schizont | possibly expressed | 0.03 | 0.98 |
| Gametocyte | expressed | 0.07 | 0.96 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1360100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.403 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IDA4
"Best" AlphaFill ligand hit: M2M (1-methoxy-2-(2-methoxyethoxy)ethane, Local RMSD=0.49) with 4ED5 (Global RMSD=10.28)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103065
Most Similar Human Ortholog: Q9BTD8
TM-align score: 0.66 | RMSD: 2.44
Seq Identity: 0.50 | Length: 132 / 180
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000126254 | RNA binding motif protein 42 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 19 | 4 | 14 |
| disruptive | 1 | 13 | 2 | 21 |
| missense | 1 | 13 | 2 | 17 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 32 | 8 | 17 |
| disruptive | 2 | 28 | 18 | 50 |
| missense | 2 | 20 | 15 | 36 |
PlasmoDB Total SNPs: 107
Non-coding: 100 | Synonymous: 5 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 180 | Molecular Weight (kDa): 21.147
UniProt ID(s): Q8IDA4
PDB ID(s): None
Isoelectric Point: 10.62
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000504 | RNA recognition motif domain |
| InterPro | IPR034215 | RBM42, RNA recognition motif |
| InterPro | IPR035979 | RNA-binding domain superfamily |
| PFam | PF00076 | RNA recognition motif domain |
| Superfamily | SSF54928 | RNA-binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 23437009 | Discovery of a splicing regulator required for cell cycle progression. | Suvorova ES, Croken M, ..., White MW | 10.1371/journal.pgen.1003305 |
| 27381095 | The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. | Bunnik EM, Batugedara G, ..., Le Roch KG | 10.1186/s13059-016-1014-0 |
| 37994298 | RRM1 and PAB domains of translation initiation factor eIF4G (Tif4631p) play acrucial role in the nuclear degradation of export-defective mRNAs inSaccharomyces cerevisiae | Saha U, Gaine R, ..., Das B | 10.1111/febs.17016 |