Genome location: Pf3D7_13_v3:2,406,644..2,408,604(-)
Genome classification: Core
Product Description: ER membrane protein complex subunit 3, putative
SignalP Peptide: N/A
# Transmembrane Domains: 3
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0072546 | EMC complex |
Process | GO:0034975 | protein folding in endoplasmic reticulum |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | possibly expressed | N/A | N/A |
Ring | expressed | 0.07 | 0.96 |
Trophozoite | expressed | 0.15 | 0.90 |
Schizont | expressed | 0.03 | 0.97 |
Gametocyte | expressed | 0.07 | 0.96 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1360200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.15 | MFS: -2.813 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1136400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IDA3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102473
Most Similar Human Ortholog: Q9P0I2
TM-align score: 0.65 | RMSD: 3.81
Seq Identity: 0.30 | Length: 213 / 257
All Human Orthologs (OrthoMCL):
Gene ID | Description |
---|---|
ENSG00000125037 | ER membrane protein complex subunit 3 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 4 | 20 | 12 | 15 |
disruptive | 3 | 13 | 6 | 27 |
missense | 3 | 13 | 6 | 26 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 10 | 35 | 7 | 24 |
disruptive | 5 | 38 | 21 | 63 |
missense | 5 | 31 | 19 | 54 |
PlasmoDB Total SNPs: 111
Non-coding: 96 | Synonymous: 12 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 257 | Molecular Weight (kDa): 29.644
UniProt ID(s): Q8IDA3
PDB ID(s): None
Isoelectric Point: 5.37
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR002809 | Integral membrane protein EMC3/TMCO1-like |
InterPro | IPR008568 | ER membrane protein complex subunit 3 |
PFam | PF01956 | Integral membrane protein EMC3/TMCO1-like |
Superfamily | N/A | N/A |
No associated publications