About Gene List

PF3D7_1360200 (EMC3)

Genome location: Pf3D7_13_v3:2,406,644..2,408,604(-)

Genome classification: Core

Function and Localization

Product Description: ER membrane protein complex subunit 3, putative

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0072546 EMC complex
Process GO:0034975 protein folding in endoplasmic reticulum

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 0.07 0.96
Trophozoite expressed 0.15 0.90
Schizont expressed 0.03 0.97
Gametocyte expressed 0.07 0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1360200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.15 | MFS: -2.813 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1136400)

  • Relative Growth Rate: 0.21 ± 0.24
  • Confidence: 4.26

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDA3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102473

Most Similar Human Ortholog: Q9P0I2

TM-align score: 0.65 | RMSD: 3.81

Seq Identity: 0.30 | Length: 213 / 257

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000125037 ER membrane protein complex subunit 3

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 20 12 15
disruptive 3 13 6 27
missense 3 13 6 26

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 10 35 7 24
disruptive 5 38 21 63
missense 5 31 19 54

PlasmoDB Total SNPs: 111

Non-coding: 96 | Synonymous: 12 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 257 | Molecular Weight (kDa): 29.644

UniProt ID(s): Q8IDA3

PDB ID(s): None

Isoelectric Point: 5.37

Protein Domain Annotations:

Source Family ID Description
InterPro IPR002809 Integral membrane protein EMC3/TMCO1-like
InterPro IPR008568 ER membrane protein complex subunit 3
PFam PF01956 Integral membrane protein EMC3/TMCO1-like
Superfamily N/A N/A

Associated Publications

No associated publications