PF3D7_1360300

Genome location: Pf3D7_13_v3:2,408,666..2,410,749(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.10	0.95
Trophozoite	possibly expressed	0.42	0.75
Schizont	expressed	0.05	0.97
Gametocyte	not expressed	0.51	0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1360300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.139 | MFS: -3.007 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1136500)

Relative Growth Rate: 0.02 ± 0.03
Confidence: 8.37

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8P5

"Best" AlphaFill ligand hit: AGS (phosphothiophosphoric acid-adenylate ester, Local RMSD=0.11) with 6HRC (Global RMSD=22.31)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532942

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	19	11	23
disruptive	13	52	37	86
missense	13	50	37	75

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	41	15	29
disruptive	22	140	56	121
missense	19	121	47	79

PlasmoDB Total SNPs: 133

Non-coding: 112 | Synonymous: 6 | Nonsynonymous: 15 | Stop Codon: 0

Protein Information

Protein Length: 372 | Molecular Weight (kDa): 45.561

UniProt ID(s): A0A5K1K8P5

PDB ID(s): None

Isoelectric Point: 9.85

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A