PF3D7_1360400

Genome location: Pf3D7_13_v3:2,411,192..2,412,387(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.25	0.88
Trophozoite	possibly expressed	0.54	0.70
Schizont	possibly expressed	0.05	0.97
Gametocyte	not expressed	0.50	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1360400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.154 | MFS: -3.161 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1136600)

Relative Growth Rate: 0.22 ± 0.29
Confidence: 3.87

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K912

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533471

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	15	11	15
disruptive	6	54	21	75
missense	6	54	20	73

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	31	16	23
disruptive	14	109	55	101
missense	12	98	47	76

PlasmoDB Total SNPs: 39

Non-coding: 21 | Synonymous: 8 | Nonsynonymous: 10 | Stop Codon: 0

Protein Information

Protein Length: 313 | Molecular Weight (kDa): 36.774

UniProt ID(s): A0A5K1K912

PDB ID(s): None

Isoelectric Point: 4.22

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A