PF3D7_1360900

Genome location: Pf3D7_13_v3:2,439,392..2,443,396(-)

Genome classification: Core

Function and Localization

Product Description: RNA-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Component	GO:1990904	ribonucleoprotein complex
Function	GO:0003723	RNA binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	nd	nd
Trophozoite	expressed	nd	nd
Schizont	expressed	nd	nd
Gametocyte	expressed	nd	nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1360900

Resistome Missense Mutations: D129Y

Resistome Compounds with Missense Mutations: MMV665794

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.472 | MFS: -2.639 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5J5

"Best" AlphaFill ligand hit: 15P (peg 1500, Local RMSD=0.13) with 6F4J (Global RMSD=5.09)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_151980

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	24	19	32
disruptive	0	6	5	24
missense	0	6	5	19

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	54	21	25
disruptive	2	32	13	75
missense	1	18	8	52

PlasmoDB Total SNPs: 276

Non-coding: 261 | Synonymous: 13 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 389 | Molecular Weight (kDa): 44.813

UniProt ID(s): C0H5J5

PDB ID(s): None

Isoelectric Point: 9.51

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000504	RNA recognition motif domain
InterPro	IPR035979	RNA-binding domain superfamily
PFam	PF00076	RNA recognition motif domain
Superfamily	SSF54928	RNA-binding domain superfamily