Genome location: Pf3D7_13_v3:2,449,531..2,453,792(+)
Genome classification: Core
Product Description: protein transport protein Sec24A
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030127 | COPII vesicle coat |
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0070971 | endoplasmic reticulum exit site |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0000149 | SNARE binding |
| Function | GO:0008270 | zinc ion binding |
| Process | GO:0090110 | COPII-coated vesicle cargo loading |
| Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| Process | GO:0043952 | protein transport by the Sec complex |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | possibly expressed | 0.69 | 0.67 |
| Trophozoite | expressed | 0.54 | 0.68 |
| Schizont | expressed | 0.66 | 0.62 |
| Gametocyte | expressed | 0.39 | 0.77 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1361100
Resistome Missense Mutations: M182I
Resistome Compounds with Missense Mutations: MMV007224
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.38 | MFS: -2.463 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1137200)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1137200)
Modification: Disrupted | RMgm-3120
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H5J6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101023
Most Similar Human Ortholog: O95486
TM-align score: 0.74 | RMSD: 3.52
Seq Identity: 0.32 | Length: 747 / 940
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000113615 | SEC24 homolog A, COPII coat complex component |
| ENSG00000138802 | SEC24 homolog B, COPII coat complex component |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 62 | 31 | 72 |
| disruptive | 14 | 51 | 40 | 96 |
| missense | 12 | 39 | 36 | 80 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 21 | 126 | 43 | 65 |
| disruptive | 29 | 130 | 75 | 188 |
| missense | 20 | 103 | 64 | 125 |
PlasmoDB Total SNPs: 191
Non-coding: 129 | Synonymous: 43 | Nonsynonymous: 17 | Stop Codon: 2
Protein Length: 940 | Molecular Weight (kDa): 106.685
UniProt ID(s): C0H5J6
PDB ID(s): None
Isoelectric Point: 7.03
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006895 | Zinc finger, Sec23/Sec24-type |
| InterPro | IPR006896 | Sec23/Sec24, trunk domain |
| InterPro | IPR006900 | Sec23/Sec24, helical domain |
| InterPro | IPR007123 | Gelsolin-like domain |
| InterPro | IPR012990 | Sec23/Sec24 beta-sandwich |
| InterPro | IPR036174 | Zinc finger, Sec23/Sec24-type superfamily |
| InterPro | IPR036175 | Sec23/Sec24 helical domain superfamily |
| InterPro | IPR036180 | Gelsolin-like domain superfamily |
| InterPro | IPR036465 | von Willebrand factor A-like domain superfamily |
| PFam | PF00626 | Gelsolin-like domain |
| PFam | PF04810 | Zinc finger, Sec23/Sec24-type |
| PFam | PF04811 | Sec23/Sec24, trunk domain |
| PFam | PF04815 | Sec23/Sec24, helical domain |
| PFam | PF08033 | Sec23/Sec24 beta-sandwich |
| Superfamily | SSF53300 | von Willebrand factor A-like domain superfamily |
| Superfamily | SSF81811 | Sec23/Sec24 helical domain superfamily |
| Superfamily | SSF81995 | Gelsolin-like domain superfamily |
| Superfamily | SSF82754 | Zinc finger, Sec23/Sec24-type superfamily |
| Superfamily | SSF82919 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 18410493 | Plasmodium falciparum Sec24 marks transitional ER that exports a model cargo viaa diacidic motif. | Lee MC, Moura PA, Miller EA, Fidock DA | 10.1111/j.1365-2958.2008.06250.x |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |