About Gene List

PF3D7_1361200

Genome location: Pf3D7_13_v3:2,454,751..2,461,569(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus
Component GO:0005667 transcription regulator complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.95 0.58
Trophozoite expressed 1.01 0.48
Schizont expressed 0.75 0.59
Gametocyte expressed 1.05 0.46

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1361200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.199 | MFS: -2.767 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ID94

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533352

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 17 128 63 125
disruptive 82 377 179 423
missense 61 335 155 345

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 48 237 92 131
disruptive 184 788 318 671
missense 131 635 244 373

PlasmoDB Total SNPs: 397

Non-coding: 166 | Synonymous: 109 | Nonsynonymous: 122 | Stop Codon: 0

Protein Information

Protein Length: 1792 | Molecular Weight (kDa): 210.164

UniProt ID(s): Q25912, Q8ID94

PDB ID(s): None

Isoelectric Point: 10.03

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
17653272 Rapid identification of malaria vaccine candidates based on alpha-helical coiledcoil protein motif. Villard V, Agak GW, ..., Corradin G 10.1371/journal.pone.0000645
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
31728527 Epigenetic reader complexes of the human malaria parasite, Plasmodium falciparum. Hoeijmakers WAM, Miao J, ..., Bartfai R 10.1093/nar/gkz1044