PF3D7_1361300

Genome location: Pf3D7_13_v3:2,461,591..2,463,928(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016020	membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.03	0.98
Schizont	not expressed	0.02	0.99
Gametocyte	expressed	1.06	0.58

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1361300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.123 | MFS: -3.105 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1137400)

Relative Growth Rate: 0.96 ± 0.11
Confidence: 5.77

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1137400)

Modification: Disrupted | RMgm-3121

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K918

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532331

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	18	11	20
disruptive	5	31	17	38
missense	5	31	17	37

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	28	12	24
disruptive	12	59	22	59
missense	12	55	20	49

PlasmoDB Total SNPs: 117

Non-coding: 103 | Synonymous: 9 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 238 | Molecular Weight (kDa): 28.178

UniProt ID(s): A0A5K1K918

PDB ID(s): None

Isoelectric Point: 9.63

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A