PF3D7_1361500

Genome location: Pf3D7_13_v3:2,464,790..2,468,539(-)

Genome classification: Core

Function and Localization

Product Description: PH domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005769	early endosome
Component	GO:0055037	recycling endosome
Component	GO:0005802	trans-Golgi network
Process	GO:0007032	endosome organization
Process	GO:0001881	receptor recycling
Process	GO:0042147	retrograde transport, endosome to Golgi

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	nd	nd
Trophozoite	expressed	nd	nd
Schizont	expressed	nd	nd
Gametocyte	expressed	nd	nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1361500.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.954 | MFS: -1.934 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5J8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_129725

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	35	18	36
disruptive	2	17	14	30
missense	2	16	14	26

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	67	26	29
disruptive	6	51	32	45
missense	6	39	28	32

PlasmoDB Total SNPs: 120

Non-coding: 115 | Synonymous: 3 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 366 | Molecular Weight (kDa): 43.216

UniProt ID(s): C0H5J8

PDB ID(s): None

Isoelectric Point: 6.67

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR024453	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
InterPro	IPR038765	Papain-like cysteine peptidase superfamily
PFam	PF00169	Pleckstrin homology domain
PFam	PF05708	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
Superfamily	SSF50729	Papain-like cysteine peptidase superfamily
Superfamily	SSF54001