PF3D7_1361600 (YfhJ)

Genome location: Pf3D7_13_v3:2,469,127..2,469,540(-)

Genome classification: Core

Function and Localization

Product Description: Fe-S assembly protein IscX, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Process	GO:0016226	iron-sulfur cluster assembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.10	0.93
Schizont	not expressed	0.06	0.95
Gametocyte	not expressed	0.15	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1361600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.18 | MFS: -2.825 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K994

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_129812

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	9	7	3
disruptive	3	12	8	18
missense	3	11	8	17

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	12	6	8
disruptive	4	28	14	38
missense	3	24	11	28

PlasmoDB Total SNPs: 5

Non-coding: 0 | Synonymous: 3 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 137 | Molecular Weight (kDa): 16.568

UniProt ID(s): A0A5K1K994

PDB ID(s): None

Isoelectric Point: 8.92

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR007479	ISC system FeS cluster assembly, IscX
InterPro	IPR036762	IscX-like superfamily
PFam	PF04384	ISC system FeS cluster assembly, IscX
Superfamily	SSF140319	IscX-like superfamily