Genome location: Pf3D7_13_v3:2,470,306..2,472,405(+)
Genome classification: Core
Product Description: cytochrome c oxidase subunit 2A, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: 1.9.3.1 (Transferred entry: 7.1.1.9)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005751 | mitochondrial respiratory chain complex IV |
| Component | GO:0005739 | mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.01 | 0.99 |
| Trophozoite | expressed | 0.09 | 0.94 |
| Schizont | expressed | 0.09 | 0.93 |
| Gametocyte | expressed | 0.11 | 0.93 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1361700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.123 | MFS: -2.837 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1137700)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A5K1K9B3
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 1.9.3.1 | cytochrome-c oxidase | No BRENDA inhibitors |
Orthology to BindingDB Entries:
Protein Length: 228 | Molecular Weight (kDa): 27.262
UniProt ID(s): A0A5K1K9B3
PDB ID(s): None
Isoelectric Point: 7.71
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 16 | 10 | 18 |
| disruptive | 3 | 25 | 20 | 30 |
| missense | 3 | 22 | 19 | 26 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 33 | 12 | 7 |
| disruptive | 7 | 51 | 28 | 57 |
| missense | 6 | 45 | 23 | 33 |
PlasmoDB Total SNPs: 41
Non-coding: 36 | Synonymous: 2 | Nonsynonymous: 3 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 18036550 | The polypeptides COX2A and COX2B are essential components of the mitochondrialcytochrome c oxidase of Toxoplasma gondii. | Morales-Sainz L, Escobar-Ramirez A, ..., Gonzalez-Halphen D | 10.1016/j.bbabio.2007.10.013 |
| 30204084 | Elucidating the mitochondrial proteome of Toxoplasma gondii reveals the presenceof a divergent cytochrome c oxidase | Seidi A, Muellner-Wong LS, ..., van Dooren GG | 10.7554/eLife.38131 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 29043530 | Cox2A/Cox2B subunit interaction in Polytomella sp. cytochrome c oxidase: role ofthe Cox2B subunit extension | Jimenez-Suarez A, Vazquez-Acevedo M, Miranda-Astudillo H, Gonzalez-Halphen D | 10.1007/s10863-017-9728-6 |
| 33863923 | Fisetin inhibits lipopolysaccharide-induced inflammatory response by activatingbeta-catenin, leading to a decrease in endotoxic shock | Molagoda IMN, Jayasingha JACC, ..., Kim GY | 10.1038/s41598-021-87257-0 |