Genome location: Pf3D7_13_v3:2,473,498..2,482,244(+)
Genome classification: Core
Product Description: glideosome-associated connector
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0045177 | apical part of cell |
| Component | GO:0009986 | cell surface |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005829 | cytosol |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0051015 | actin filament binding |
| Process | GO:0071976 | cell gliding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.45 | 0.83 |
| Trophozoite | expressed | 0.40 | 0.79 |
| Schizont | expressed | 2.77 | 0.10 |
| Gametocyte | expressed | 0.57 | 0.69 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1361800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.046 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1137800)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1137800)
Modification: Tagged | RMgm-4058
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A5K1K8J3
"Best" AlphaFill ligand hit: UPL (unknown branched fragment of phospholipid, Local RMSD=0.02) with 1LSH (Global RMSD=21.54)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 17 | 79 | 66 | 151 |
| disruptive | 26 | 84 | 63 | 168 |
| missense | 26 | 84 | 57 | 163 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 28 | 180 | 100 | 159 |
| disruptive | 39 | 165 | 81 | 247 |
| missense | 38 | 155 | 79 | 224 |
PlasmoDB Total SNPs: 134
Non-coding: 49 | Synonymous: 44 | Nonsynonymous: 41 | Stop Codon: 0
Protein Length: 2605 | Molecular Weight (kDa): 291.023
UniProt ID(s): A0A5K1K8J3
PDB ID(s): None
Isoelectric Point: 4.87
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000225 | Armadillo |
| InterPro | IPR016024 | Armadillo-type fold |
| InterPro | IPR040104 | Armadillo repeat-containing protein 6 |
| PFam | N/A | N/A |
| Superfamily | SSF48371 | Armadillo-type fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 23197789 | Proteomic and genetic analyses demonstrate that Plasmodium berghei blood stagesexport a large and diverse repertoire of proteins. | Pasini EM, Braks JA, ..., Franke-Fayard B | 10.1074/mcp.M112.021238 |
| 27714937 | PlasmoSEP: Predicting surface-exposed proteins on the malaria parasite usingsemisupervised self-training and expert-annotated data. | El-Manzalawy Y, Munoz EE, Lindner SE, Honavar V | 10.1002/pmic.201600249 |
| 27978434 | An Apicomplexan Actin-Binding Protein Serves as a Connector and Lipid Sensor toCoordinate Motility and Invasion. | Jacot D, Tosetti N, ..., Soldati-Favre D | 10.1016/j.chom.2016.10.020 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |