PF3D7_1362300 (TMCO1)

Genome location: Pf3D7_13_v3:2,492,607..2,494,181(+)

Genome classification: Core

Function and Localization

Product Description: transmembrane and coiled-coil domain-containing protein 1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Function	GO:0005262	calcium channel activity
Process	GO:0006874	cellular calcium ion homeostasis

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.12	0.94
Trophozoite	expressed	0.27	0.83
Schizont	expressed	0.03	0.98
Gametocyte	expressed	0.14	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1362300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.425 | MFS: -3.115 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ID84

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104181

Most Similar Human Ortholog: Q9UM00

TM-align score: 0.75 | RMSD: 2.89

Seq Identity: 0.27 | Length: 173 / 189

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000143183	transmembrane and coiled-coil domains 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	17	10	17
disruptive	0	12	5	27
missense	0	12	5	26

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	32	13	10
disruptive	2	34	34	53
missense	0	26	27	39

PlasmoDB Total SNPs: 76

Non-coding: 65 | Synonymous: 7 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 189 | Molecular Weight (kDa): 22.064

UniProt ID(s): Q8ID84

PDB ID(s): None

Isoelectric Point: 9.21

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR002809	Integral membrane protein EMC3/TMCO1-like
InterPro	IPR008559	Calcium load-activated calcium channel
PFam	PF01956	Integral membrane protein EMC3/TMCO1-like
Superfamily	N/A	N/A