PF3D7_1362600

Genome location: Pf3D7_13_v3:2,505,912..2,507,356(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	possibly expressed	0.05	0.97
Schizont	expressed	0.05	0.96
Gametocyte	expressed	1.76	0.53

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1362600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.877 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1138600)

Relative Growth Rate: 0.99 ± 0.14
Confidence: 5.25

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1138600)

Modification: Disrupted | RMgm-3129

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K9G2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_106389

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	17	7	13
disruptive	4	27	17	34
missense	4	27	17	33

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	30	5	24
disruptive	7	58	23	67
missense	7	54	18	50

PlasmoDB Total SNPs: 92

Non-coding: 73 | Synonymous: 14 | Nonsynonymous: 3 | Stop Codon: 2

Protein Information

Protein Length: 267 | Molecular Weight (kDa): 32.13

UniProt ID(s): A0A5K1K9G2

PDB ID(s): None

Isoelectric Point: 9.13

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A