PF3D7_1362700

Genome location: Pf3D7_13_v3:2,509,007..2,517,549(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.10	0.96
Trophozoite	possibly expressed	0.52	0.72
Schizont	possibly expressed	0.45	0.74
Gametocyte	expressed	1.52	0.34

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1362700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.065 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5K2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533770

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	20	96	46	110
disruptive	161	449	199	489
missense	87	352	161	370

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	33	179	63	114
disruptive	292	774	292	575
missense	172	582	223	374

PlasmoDB Total SNPs: 1057

Non-coding: 237 | Synonymous: 392 | Nonsynonymous: 428 | Stop Codon: 0

Protein Information

Protein Length: 2039 | Molecular Weight (kDa): 242.24

UniProt ID(s): C0H5K2

PDB ID(s): None

Isoelectric Point: 4.22

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A