PF3D7_1362800

Genome location: Pf3D7_13_v3:2,518,311..2,525,712(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.07	0.97
Trophozoite	not expressed	0.33	0.80
Schizont	expressed	0.77	0.56
Gametocyte	expressed	0.28	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1362800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.265 | #Insertions: 11

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1138800)

Relative Growth Rate: 0.39 ± 0.12
Confidence: 5.57

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1138800)

Modification: Disrupted | RMgm-3131

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5K3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533470

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	15	109	84	147
disruptive	42	279	145	405
missense	39	274	144	384

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	37	221	116	152
disruptive	82	570	236	517
missense	70	529	221	425

PlasmoDB Total SNPs: 227

Non-coding: 91 | Synonymous: 72 | Nonsynonymous: 64 | Stop Codon: 0

Protein Information

Protein Length: 2183 | Molecular Weight (kDa): 263.612

UniProt ID(s): C0H5K3

PDB ID(s): None

Isoelectric Point: 5.36

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A