PF3D7_1362900

Genome location: Pf3D7_13_v3:2,526,360..2,531,483(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.03	0.99
Trophozoite	possibly expressed	0.17	0.90
Schizont	possibly expressed	0.26	0.84
Gametocyte	expressed	1.07	0.56

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1362900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.17 | #Insertions: 12

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1138900)

Modification: Disrupted | RMgm-3132

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K924

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533231

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	68	41	100
disruptive	58	207	126	296
missense	41	186	115	260

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	25	133	66	104
disruptive	99	440	206	358
missense	67	374	174	273

PlasmoDB Total SNPs: 328

Non-coding: 30 | Synonymous: 202 | Nonsynonymous: 96 | Stop Codon: 0

Protein Information

Protein Length: 1636 | Molecular Weight (kDa): 196.229

UniProt ID(s): A0A5K1K924

PDB ID(s): None

Isoelectric Point: 8.68

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A