PF3D7_1363100

Genome location: Pf3D7_13_v3:2,535,745..2,539,767(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.14	0.93
Trophozoite	not expressed	0.49	0.71
Schizont	expressed	0.31	0.80
Gametocyte	not expressed	0.57	0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1363100

Resistome Missense Mutations: I345K

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.246 | MFS: -3.349 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K9B5

"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=5.91) with 2PML (Global RMSD=17.85)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533489

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	51	31	68
disruptive	21	132	82	233
missense	21	126	82	220

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	15	93	47	78
disruptive	49	310	149	236
missense	31	288	135	197

PlasmoDB Total SNPs: 192

Non-coding: 134 | Synonymous: 34 | Nonsynonymous: 24 | Stop Codon: 0

Protein Information

Protein Length: 1024 | Molecular Weight (kDa): 124.754

UniProt ID(s): A0A5K1K9B5

PDB ID(s): None

Isoelectric Point: 6.06

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A