PF3D7_1363300

Genome location: Pf3D7_13_v3:2,542,180..2,543,589(+)

Genome classification: Core

Function and Localization

Product Description: 50S ribosomal protein L9, mitochondrial, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	possibly expressed	0.15	0.91
Schizont	not expressed	0.03	0.98
Gametocyte	not expressed	0.18	0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1363300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.043 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1139300)

Relative Growth Rate: 0.10 ± 0.04
Confidence: 7.97

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8K5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_151579

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	12	12	24
disruptive	4	22	18	37
missense	4	21	18	35

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	32	21	20
disruptive	9	56	32	61
missense	8	52	31	42

PlasmoDB Total SNPs: 97

Non-coding: 74 | Synonymous: 14 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 250 | Molecular Weight (kDa): 30.538

UniProt ID(s): A0A5K1K8K5

PDB ID(s): None

Isoelectric Point: 9.75

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000244	Ribosomal protein L9
InterPro	IPR009027	Ribosomal protein L9/RNase H1, N-terminal
InterPro	IPR020070	Ribosomal protein L9, N-terminal
PFam	PF01281	Ribosomal protein L9, N-terminal
Superfamily	SSF55658	Ribosomal protein L9/RNase H1, N-terminal