Genome location: Pf3D7_13_v3:2,543,068..2,547,394(-)
Genome classification: Core
Product Description: polyubiquitin binding protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB): None
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.29 | 0.86 |
| Trophozoite | expressed | 0.71 | 0.61 |
| Schizont | expressed | 0.33 | 0.79 |
| Gametocyte | expressed | 0.69 | 0.63 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1363400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.984 | MFS: -2.564 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A5K1K8W0
"Best" AlphaFill ligand hit: SIW (keggin (sta), Local RMSD=0.02) with 6Y7O (Global RMSD=8.23)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101801
Most Similar Human Ortholog: E5RIM3
TM-align score: 0.49 | RMSD: 2.29
Seq Identity: 0.26 | Length: 315 / 905
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000137055 | phospholipase A2 activating protein |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 17 | 59 | 34 | 67 |
| disruptive | 22 | 81 | 59 | 176 |
| missense | 17 | 79 | 56 | 145 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 32 | 97 | 44 | 66 |
| disruptive | 42 | 218 | 115 | 273 |
| missense | 30 | 185 | 93 | 200 |
PlasmoDB Total SNPs: 159
Non-coding: 93 | Synonymous: 39 | Nonsynonymous: 27 | Stop Codon: 0
Protein Length: 905 | Molecular Weight (kDa): 107.614
UniProt ID(s): A0A5K1K8W0
PDB ID(s): None
Isoelectric Point: 7.37
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001680 | WD40 repeat |
| InterPro | IPR013535 | PUL domain |
| InterPro | IPR015155 | PLAA family ubiquitin binding domain |
| InterPro | IPR019775 | WD40 repeat, conserved site |
| InterPro | IPR033510 | PLAA/Doa1/Lub1 |
| InterPro | IPR036322 | WD40-repeat-containing domain superfamily |
| PFam | PF00400 | WD40 repeat |
| PFam | PF08324 | PUL domain |
| PFam | PF09070 | PLAA family ubiquitin binding domain |
| Superfamily | SSF50978 | WD40-repeat-containing domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 33751052 | Reduced gene dosage of histone H4 prevents CENP-A mislocalization and chromosomalinstability in Saccharomyces cerevisiae | Eisenstatt JR, Ohkuni K, ..., Basrai MA | 10.1093/genetics/iyab033 |
| 29721631 | Multiple chemo-genetic interactions between a toxic metabolite and the ubiquitinpathway in yeast | Albrecht D, Hurlimann HC, ..., Daignan-Fornier B | 10.1007/s00294-018-0843-7 |
| 23525333 | A novel role of the N terminus of budding yeast histone H3 variant Cse4 inubiquitin-mediated proteolysis | Au WC, Dawson AR, ..., Basrai MA | 10.1534/genetics.113.149898 |