PF3D7_1364000

Genome location: Pf3D7_13_v3:2,563,135..2,567,108(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.24	0.88
Trophozoite	not expressed	0.41	0.75
Schizont	possibly expressed	0.71	0.60
Gametocyte	not expressed	0.33	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1364000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.034 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K9G3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_134686

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	40	28	45
disruptive	11	57	36	105
missense	9	50	34	89

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	82	23	67
disruptive	22	148	77	186
missense	15	116	66	137

PlasmoDB Total SNPs: 108

Non-coding: 79 | Synonymous: 15 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 827 | Molecular Weight (kDa): 97.401

UniProt ID(s): A0A5K1K9G3

PDB ID(s): None

Isoelectric Point: 6.92

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A