About Gene List

PF3D7_1364100 (P92)

Genome location: Pf3D7_13_v3:2,568,534..2,571,611(+)

Genome classification: Core

Function and Localization

Product Description: 6-cysteine protein P92

SignalP Peptide: MFAVNLKICIFLSLVSFLLQCKNTLA

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0046658 anchored component of plasma membrane
Component GO:0009986 cell surface
Function GO:0005515 protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.10 0.95
Trophozoite expressed 0.66 0.66
Schizont expressed 0.89 0.58
Gametocyte expressed 0.33 0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1364100

Resistome Missense Mutations: T304P

Resistome Compounds with Missense Mutations: BI-2536

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 1.157 | #Insertions: 5

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ID66

"Best" AlphaFill ligand hit: SAM (s-adenosylmethionine, Local RMSD=6.22) with 5NFJ (Global RMSD=16.09)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532716

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 35 24 57
disruptive 28 102 46 117
missense 26 102 46 107

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 9 75 42 55
disruptive 53 180 92 188
missense 49 165 87 120

PlasmoDB Total SNPs: 139

Non-coding: 57 | Synonymous: 48 | Nonsynonymous: 33 | Stop Codon: 1

Protein Information

Protein Length: 796 | Molecular Weight (kDa): 92.728

UniProt ID(s): A0A5K1K931, C5HDV9, C5HDW0, C5HDW3, C5HDW5, C5HDW6, C5HDW7, C5HDW9, C5HDX1, C5HDX2, C5HDX3, C5HDX4, C5HX87, C5HX92, C5HXB4, C5HXB5, Q8ID66

PDB ID(s): None

Isoelectric Point: 6.9

Protein Domain Annotations:

Source Family ID Description
InterPro IPR010884 6-Cysteine (6-Cys) domain
PFam PF07422 6-Cysteine (6-Cys) domain
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16203726 Distinct protein classes including novel merozoite surface antigens in Raft-likemembranes of Plasmodium falciparum. Sanders PR, Gilson PR, ..., Crabb BS 10.1074/jbc.M509631200
16603573 Identification and stoichiometry of glycosylphosphatidylinositol-anchoredmembrane proteins of the human malaria parasite Plasmodium falciparum. Gilson PR, Nebl T, ..., Crabb BS 10.1074/mcp.M600035-MCP200
26700768 Recruitment of Factor H as a Novel Complement Evasion Strategy for Blood-StagePlasmodium falciparum Infection. Kennedy AT, Schmidt CQ, ..., Tham WH 10.4049/jimmunol.1501581