Genome location: Pf3D7_13_v3:2,571,524..2,578,165(-)
Genome classification: Core
Product Description: nucleoporin NUP205, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005643 | nuclear pore |
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 1.61 | 0.36 |
| Trophozoite | expressed | 0.91 | 0.52 |
| Schizont | expressed | 0.52 | 0.70 |
| Gametocyte | possibly expressed | 0.67 | 0.64 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1364200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.285 | #Insertions: 7
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1140100)
Modification: Tagged | RMgm-5241
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A5K1K9A0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 19 | 121 | 59 | 137 |
| disruptive | 71 | 280 | 167 | 387 |
| missense | 48 | 254 | 153 | 342 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 46 | 208 | 95 | 144 |
| disruptive | 113 | 654 | 254 | 532 |
| missense | 79 | 546 | 233 | 401 |
PlasmoDB Total SNPs: 235
Non-coding: 47 | Synonymous: 92 | Nonsynonymous: 96 | Stop Codon: 0
Protein Length: 1813 | Molecular Weight (kDa): 207.289
UniProt ID(s): A0A5K1K9A0
PDB ID(s): None
Isoelectric Point: 9.28
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30050042 | Nuclear Pore Complex Components in the Malaria Parasite Plasmodium berghei. | Kehrer J, Kuss C, ..., Frischknecht F | 10.1038/s41598-018-29590-5 |