About Gene List

PF3D7_1364400

Genome location: Pf3D7_13_v3:2,583,838..2,595,100(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0000123 histone acetyltransferase complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.88 0.60
Trophozoite possibly expressed 1.14 0.43
Schizont not expressed 0.76 0.58
Gametocyte not expressed 0.79 0.59

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1364400

Resistome Missense Mutations: N2894T

Resistome Compounds with Missense Mutations: Cipargamin/KAE609/NITD609

Resistome # Samples with Disruptive Mutations: 3 (3 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.126 | MFS: -3.128 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1140300)

Modification: Disrupted | RMgm-731

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532395

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 33 202 116 190
disruptive 130 523 263 662
missense 89 450 226 537

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 64 373 146 254
disruptive 281 1111 495 1021
missense 182 870 388 616

PlasmoDB Total SNPs: 588

Non-coding: 127 | Synonymous: 236 | Nonsynonymous: 225 | Stop Codon: 0

Protein Information

Protein Length: 3265 | Molecular Weight (kDa): 386.33

UniProt ID(s): A0A5K1K8L4

PDB ID(s): None

Isoelectric Point: 8.78

Protein Domain Annotations:

Source Family ID Description
InterPro IPR036915 Cyclin-like superfamily
PFam N/A N/A
Superfamily SSF47954 Cyclin-like superfamily

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
34403450 A unique GCN5 histone acetyltransferase complex controls erythrocyte invasion andvirulence in the malaria parasite Plasmodium falciparum. Miao J, Wang C, ..., Cui L 10.1371/journal.ppat.1009351