PF3D7_1364600

Genome location: Pf3D7_13_v3:2,598,355..2,601,731(+)

Genome classification: Core

Function and Localization

Product Description: aldehyde reductase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 1.1.1.21 (Aldose reductase)

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast
Function	GO:0004033	aldo-keto reductase (NADP) activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.07	0.96
Trophozoite	expressed	0.66	0.64
Schizont	expressed	0.38	0.78
Gametocyte	expressed	0.43	0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1364600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.152 | MFS: -2.855 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ID61

"Best" AlphaFill ligand hit: FID ((2s,4s)-2-aminoformyl-6-fluoro-spiro[chroman-4,4'-imidazolidine]-2',5'-dione, Local RMSD=0.03) with 4GAB (Global RMSD=6.22)

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
1.1.1.21	aldose reductase	BRENDA SOAP query unsuccessful

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101126

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	18	53	26	55
disruptive	25	87	41	138
missense	23	75	40	118

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	26	96	34	67
disruptive	41	163	82	192
missense	33	133	73	142

PlasmoDB Total SNPs: 119

Non-coding: 48 | Synonymous: 43 | Nonsynonymous: 28 | Stop Codon: 0

Protein Information

Protein Length: 880 | Molecular Weight (kDa): 106.122

UniProt ID(s): Q8ID61

PDB ID(s): None

Isoelectric Point: 9.52

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR023210	NADP-dependent oxidoreductase domain
InterPro	IPR036812	NADP-dependent oxidoreductase domain superfamily
PFam	PF00248	NADP-dependent oxidoreductase domain
Superfamily	SSF51430	NADP-dependent oxidoreductase domain superfamily