PF3D7_1365000

Genome location: Pf3D7_13_v3:2,608,363..2,610,359(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.22	0.89
Trophozoite	expressed	0.34	0.80
Schizont	possibly expressed	0.07	0.95
Gametocyte	expressed	0.46	0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1365000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.3 | MFS: -2.627 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8X0

"Best" AlphaFill ligand hit: LVV (4-[(4-methylphenyl)methyl]-1,4-thiazinane 1,1-dioxide, Local RMSD=0.07) with 5S66 (Global RMSD=22.35)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533453

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	20	6	23
disruptive	3	75	38	72
missense	3	72	38	71

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	41	16	20
disruptive	16	142	59	96
missense	9	133	54	84

PlasmoDB Total SNPs: 59

Non-coding: 27 | Synonymous: 16 | Nonsynonymous: 16 | Stop Codon: 0

Protein Information

Protein Length: 348 | Molecular Weight (kDa): 42.221

UniProt ID(s): A0A5K1K8X0

PDB ID(s): None

Isoelectric Point: 9.59

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A