Genome location: Pf3D7_13_v3:2,609,807..2,610,960(-)
Genome classification: Core
Product Description: ribosomal protein S17, mitochondrial
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022627 | cytosolic small ribosomal subunit |
| Component | GO:0005763 | mitochondrial small ribosomal subunit |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0000314 | organellar small ribosomal subunit |
| Component | GO:0005840 | ribosome |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0032543 | mitochondrial translation |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | possibly expressed | 0.02 | 0.99 |
| Trophozoite | possibly expressed | 0.06 | 0.96 |
| Schizont | not expressed | 0.00 | 1.00 |
| Gametocyte | possibly expressed | 0.06 | 0.96 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1365100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.643 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ID56
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100208
Most Similar Human Ortholog: M0R1H5
TM-align score: 0.71 | RMSD: 1.64
Seq Identity: 0.16 | Length: 68 / 115
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000142534 | ribosomal protein S11 |
| ENSG00000239789 | mitochondrial ribosomal protein S17 |
| ENSG00000249773 | novel zinc finger protein 713 (ZNF713) and mitochondrial ribosomal protein S17 (MRPS17) protein |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 74
Non-coding: 74 | Synonymous: 0 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 115 | Molecular Weight (kDa): 13.971
UniProt ID(s): Q8ID56
PDB ID(s): None
Isoelectric Point: 10.5
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000266 | Ribosomal protein S17/S11 |
| InterPro | IPR012340 | Nucleic acid-binding, OB-fold |
| PFam | PF00366 | Ribosomal protein S17/S11 |
| Superfamily | SSF50249 | Nucleic acid-binding, OB-fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 32273345 | Genetic ablation of the mitoribosome in the malaria parasite Plasmodiumfalciparum sensitizes it to antimalarials that target mitochondrial functions. | Ling L, Mulaka M, ..., Ke H | 10.1074/jbc.RA120.012646 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |