About Gene List

PF3D7_1365700

Genome location: Pf3D7_13_v3:2,624,097..2,627,647(-)

Genome classification: Core

Function and Localization

Product Description: SNARE associated Golgi protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 6

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0016020 membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 0.15 0.92
Trophozoite possibly expressed 0.24 0.84
Schizont expressed 0.53 0.66
Gametocyte not expressed 0.29 0.83

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1365700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.988 | MFS: -0.403 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1141500)

  • Relative Growth Rate: 0.01 ± 0.09
  • Confidence: 6.19

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ID52

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_108915

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 0 0 0 1
missense 0 0 0 0

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 0 0 0 2
missense 0 0 0 0

PlasmoDB Total SNPs: 186

Non-coding: 166 | Synonymous: 15 | Nonsynonymous: 4 | Stop Codon: 1

Protein Information

Protein Length: 408 | Molecular Weight (kDa): 47.02

UniProt ID(s): Q8ID52

PDB ID(s): None

Isoelectric Point: 8.73

Protein Domain Annotations:

Source Family ID Description
InterPro IPR015414 Transmembrane protein TMEM64
InterPro IPR032816 SNARE associated Golgi protein
PFam PF09335 SNARE associated Golgi protein
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104