PF3D7_1365800

Genome location: Pf3D7_13_v3:2,629,805..2,631,978(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.24	0.87
Trophozoite	expressed	0.29	0.82
Schizont	expressed	0.41	0.73
Gametocyte	possibly expressed	0.40	0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1365800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.127 | MFS: -2.953 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K961

"Best" AlphaFill ligand hit: SAM (s-adenosylmethionine, Local RMSD=29.37) with 6P78 (Global RMSD=32.70)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532553

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	19	15	23
disruptive	2	10	10	32
missense	2	10	10	25

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	38	15	21
disruptive	5	44	24	90
missense	4	27	18	53

PlasmoDB Total SNPs: 148

Non-coding: 136 | Synonymous: 9 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 329 | Molecular Weight (kDa): 39.035

UniProt ID(s): A0A5K1K961

PDB ID(s): None

Isoelectric Point: 10.05

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A