Product Description: ubiquitin-60S ribosomal protein L40
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0022625 | cytosolic large ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0031386 | protein tag |
| Function | GO:0003735 | structural constituent of ribosome |
| Function | GO:0031625 | ubiquitin protein ligase binding |
| Process | GO:0006464 | cellular protein modification process |
| Process | GO:0019941 | modification-dependent protein catabolic process |
| Process | GO:0016567 | protein ubiquitination |
| Process | GO:0006412 | translation |
| Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.71 | 0.29 |
| Trophozoite | expressed | 1.83 | 0.23 |
| Schizont | expressed | 1.03 | 0.43 |
| Gametocyte | expressed | 1.94 | 0.19 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1365900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.119 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ID50
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q15843 | NEDD8 | OrthoMCL BLAST | Pevonedistat |
Ortholog Group (OrthoMCL): OG6_101560
Most Similar Human Ortholog: M0R1V7
TM-align score: 0.97 | RMSD: 0.63
Seq Identity: 0.98 | Length: 63 / 128
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000221983 | ubiquitin A-52 residue ribosomal protein fusion product 1 |
Protein Length: 128 | Molecular Weight (kDa): 14.617
UniProt ID(s): Q8ID50
PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD
Isoelectric Point: 10.55
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000626 | Ubiquitin-like domain |
| InterPro | IPR001975 | Ribosomal protein L40e |
| InterPro | IPR011332 | Zinc-binding ribosomal protein |
| InterPro | IPR019954 | Ubiquitin conserved site |
| InterPro | IPR019956 | Ubiquitin domain |
| InterPro | IPR029071 | Ubiquitin-like domain superfamily |
| PFam | PF00240 | Ubiquitin-like domain |
| PFam | PF01020 | Ribosomal protein L40e |
| Superfamily | SSF54236 | Ubiquitin-like domain superfamily |
| Superfamily | SSF57829 | Zinc-binding ribosomal protein |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 1 | 1 | 1 | 1 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 3 | 1 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 144
Non-coding: 137 | Synonymous: 7 | Nonsynonymous: 0 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 24913268 | Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine | Wong W, Bai XC, ..., Scheres SH | 10.7554/eLife.03080 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |