About Gene List

PF3D7_1365900

Genome location: Pf3D7_13_v3:2,632,304..2,634,360(-)

Genome classification: Core

Function and Localization

Product Description: ubiquitin-60S ribosomal protein L40

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005737 cytoplasm
Component GO:0022625 cytosolic large ribosomal subunit
Component GO:0005634 nucleus
Function GO:0003723 RNA binding
Function GO:0031386 protein tag
Function GO:0003735 structural constituent of ribosome
Function GO:0031625 ubiquitin protein ligase binding
Process GO:0006464 cellular protein modification process
Process GO:0019941 modification-dependent protein catabolic process
Process GO:0016567 protein ubiquitination
Process GO:0006412 translation
Process GO:0006511 ubiquitin-dependent protein catabolic process

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 1.71 0.29
Trophozoite expressed 1.83 0.23
Schizont expressed 1.03 0.43
Gametocyte expressed 1.94 0.19

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1365900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.119 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ID50

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

Orthology to BindingDB Entries:

UniProt Protein Name Species Homology Source BindingDB Ligands
Q15843 NEDD8 OrthoMCL BLAST Pevonedistat

Orthology Information

Ortholog Group (OrthoMCL): OG6_101560

Most Similar Human Ortholog: M0R1V7

TM-align score: 0.97 | RMSD: 0.63

Seq Identity: 0.98 | Length: 63 / 128

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000221983 ubiquitin A-52 residue ribosomal protein fusion product 1

Protein Information

Protein Length: 128 | Molecular Weight (kDa): 14.617

UniProt ID(s): Q8ID50

PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD

Isoelectric Point: 10.55

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000626 Ubiquitin-like domain
InterPro IPR001975 Ribosomal protein L40e
InterPro IPR011332 Zinc-binding ribosomal protein
InterPro IPR019954 Ubiquitin conserved site
InterPro IPR019956 Ubiquitin domain
InterPro IPR029071 Ubiquitin-like domain superfamily
PFam PF00240 Ubiquitin-like domain
PFam PF01020 Ribosomal protein L40e
Superfamily SSF54236 Ubiquitin-like domain superfamily
Superfamily SSF57829 Zinc-binding ribosomal protein

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 1 1 1 1
missense 0 0 0 0

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 3 1 0 0
missense 0 0 0 0

PlasmoDB Total SNPs: 144

Non-coding: 137 | Synonymous: 7 | Nonsynonymous: 0 | Stop Codon: 0

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
24913268 Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine Wong W, Bai XC, ..., Scheres SH 10.7554/eLife.03080
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596
33906926 Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH Sinha A, Baumgarten S, ..., Scherf A 10.1128/mBio.00661-21