Genome location: Pf3D7_13_v3:2,636,101..2,637,601(+)
Genome classification: Core
Product Description: DIP13 homolog, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020007 | apical complex |
| Component | GO:0005813 | centrosome |
| Component | GO:0036064 | ciliary basal body |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.04 | 0.98 |
| Trophozoite | not expressed | 0.01 | 0.99 |
| Schizont | not expressed | 0.16 | 0.90 |
| Gametocyte | not expressed | 0.06 | 0.96 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1366100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.31 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H5K7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104424
Most Similar Human Ortholog: O43805
TM-align score: 0.86 | RMSD: 1.70
Seq Identity: 0.43 | Length: 113 / 127
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000176101 | SS nuclear autoantigen 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 6 | 2 | 3 |
| disruptive | 1 | 6 | 2 | 10 |
| missense | 1 | 4 | 2 | 6 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 7 | 3 | 4 |
| disruptive | 2 | 15 | 8 | 24 |
| missense | 2 | 11 | 5 | 13 |
PlasmoDB Total SNPs: 59
Non-coding: 57 | Synonymous: 2 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 127 | Molecular Weight (kDa): 15.063
UniProt ID(s): C0H5K7
PDB ID(s): None
Isoelectric Point: 9.03
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR033362 | SSNA1 family |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 22363749 | The orthologue of Sjogren's syndrome nuclear autoantigen 1 (SSNA1) in Trypanosomabrucei is an immunogenic self-assembling molecule | Price HP, Hodgkinson MR, ..., Smith DF | 10.1371/journal.pone.0031842 |
| 27324377 | An evolutionarily conserved SSNA1/DIP13 homologue is a component of both basaland apical complexes of Toxoplasma gondii | Leveque MF, Berry L, Besteiro S | 10.1038/srep27809 |