PF3D7_1366200

Genome location: Pf3D7_13_v3:2,637,892..2,639,016(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.07	0.97
Trophozoite	expressed	0.38	0.77
Schizont	expressed	0.15	0.90
Gametocyte	expressed	0.25	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1366200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.131 | MFS: -3.202 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1142000)

Relative Growth Rate: 0.16 ± 0.12
Confidence: 5.66

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8S1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_160753

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 90

Non-coding: 84 | Synonymous: 4 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 150 | Molecular Weight (kDa): 17.823

UniProt ID(s): A0A5K1K8S1

PDB ID(s): None

Isoelectric Point: 10.59

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A